English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The fungal strain  Alternaria alternata  JS0515 was isolated from  Vitex rotundifolia  (beach vitex). Twelve secondary metabolites, including one new altenusin derivative ( 1 ), were isolated. The isolated metabolites included seven known altenusin derivatives ( 2 – 8 ), two isochromanones ( 9 ,  10 ), one perylenequinone ( 11 ), and one benzocycloalkanone ( 12 ). Their structures were determined via 1D and 2D nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), and computational electronic circular dichroism (ECD) analysis. Compounds  3  and  11  increased pyruvate dehydrogenase (PDH) activity in AD-293 human embryonic kidney cells and significantly inhibited PDH phosphorylation. The IC 50  values of  3  and  11  were 32.58 and 27.82 μM, respectively.

molecules/molecules online/molecules annual

Secondary Metabolites of The Endophytic Fungus Alternaria alternata JS0515 Isolated from Vitex rotundifolia and Their Effects on Pyruvate Dehydrogenase activity