English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

A phytochemical study of the root and bark of  Brucea antidysenterica  J. F. Mill. (Simaroubaceae) afforded three new compounds, including a stilbene glycoside bruceanoside A ( 1 ), and two canthinone alkaloids bruceacanthinones A ( 3 ) and B ( 4 ), along with ten known secondary metabolites, rhaponticin ( 2 ), 1,11-dimethoxycanthin-6-one ( 5 ), canthin-6-one ( 6 ), 1-methoxycanthin-6-one ( 7 ), 2-methoxycanthin-6-one ( 8 ), 2-hydroxy-1,11-dimethoxycanthin-6-one ( 9 ),  β -carboline-1-propionic acid ( 10 ), cleomiscosin C ( 11 ), cleomiscosin A ( 12 ), and hydnocarpin ( 13 ). The structures of all the compounds were determined using spectrometric and spectroscopic methods including 1D and 2D NMR, and HRSEIMS. The identities of the known compounds were further confirmed by comparison of their data with those reported in the literature. The root and bark methanolic extracts, the dichloromethane and ethyl acetate soluble fractions, and the isolated compounds ( 3 – 13 ), were assessed for their cytotoxicity against the cancer cell lines A-549, MCF-7, and PC-3. The results suggested that compounds in the extracts might possess a synergic action in their cytotoxicity.

Cytotoxic Stilbenes and Canthinone Alkaloids from Brucea antidysenterica (Simaroubaceae)