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The dried vine stems of Spatholobus suberectus are commonly used in traditional Chinese medicine for treating gynecological and cardiovascular diseases. In this study, five new compounds named spasuberol A ( 2 ), homovanillyl-4-oxo-nonanoate ( 5 ), spasuberol C ( 6 ), spasuberoside A ( 14 ), and spasuberoside B ( 15 ), together with ten known compounds ( 1 , 3 , 4 , 7 - 13 ), were isolated from the dried vine stems of S. suberectus . Their chemical structures were analyzed using spectroscopic assays. This is the first study interpreting the detailed structural information of 4 . The anti-inflammatory activity of these compounds was evaluated by reducing nitric oxide overproduction in RAW264.7 macrophages stimulated by lipopolysaccharide. Compounds 1 and 8 - 10 showed strong inhibitory activity with half maximal inhibitory concentration (IC 50 ) values of 5.69, 16.34, 16.87, and 6.78 μM, respectively, exhibiting higher activity than the positive drug l- N  6 -(1-iminoethyl)-lysine (l-NIL) with an IC 50 value of 19.08 μM. The IC 50 values of inhibitory activity of compounds 2 and 4 - 6 were 46.26, 40.05, 45.87, and 28.29 μM respectively, which were lower than l-NIL, but better than that of positive drug indomethacin with an IC 50 value of 55.44 μM. Quantitative real-time polymerase chain reaction analysis revealed that assayed compounds with good anti-inflammatory activity, such as 1 , 6 , 9 , and 10 at different concentrations, can reduce the messenger RNA (mRNA) expression of some pro-inflammatory cytokines such as tumor necrosis factor α (TNF-α), nitric oxide synthase (iNOS), and cyclooxygenase 2 (COX-2). The anti-inflammatory activity and the possible mechanism of the compounds mentioned in this paper were studied preliminarily.

Anti-Inflammatory Activity of Some Characteristic Constituents from the Vine Stems of Spatholobus suberectus