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An efficient approach for the synthesis of phosphorylated isoindoline fused with triazoles via Zn(OTf) 2 -catalyzed cascade cyclization of easily prepared ortho-propynol benzyl azides and diarylphosphine oxides is developed. The transformation occurred smoothly in moderate to excellent yields and tolerated various propargylic alcohol substrates.

molecules/molecules online/molecules annual

An Efficient Approach to Phosphorylated Isoindoline Fused with Triazoles via Zn-Catalyzed Cascade Cyclization of 2–Propynol Benzyl Azides and Diarylphosphine Oxides