English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Currently, the use of synthetic pesticides is the main method of plant protection applied in agri- and horticulture. However, its excessive use leads to the development of pesticide resistance, a contamination of the environment, toxicity to non-target organisms, and risks for human health. With the ultimate aim of contributing to the develop of a more sustainable pest management, we used the natural product germacrone ( compound  1 ), reported to possess significant insecticidal activity, as starting material for the generation of molecular diversity ( 2 - 24 ). Some of the generated derivatives are natural compounds, such as 1,10-epoxygermacrone ( 2 ), 4,5-epoxygermacrone ( 3 ), gajutsulactone A ( 7 ), germacrol ( 11 ), isogermacrone ( 14 ), 9-hydroxyeudesma-3,7(11)dien-6-one ( 19 ), eudesma-4,7(11),dien-8-one ( 20 ), eudesma-3,7(11)-dien-8-one ( 21 ) and eudesma-4(15),7(11)-dien-8-one ( 22 ). Compounds, 7,11-9,10-diepoxigermacr-4,5-en-8-ol ( 17) , 7,11-epoxieudesma-4,7(11)-dien-8-one ( 23 ) and 7,11-epoxieudesma-3,7(11)-dien-8-one ( 24 ) are described for the first time. The biocidal activity of most of these compounds was assayed against the tick Hyalomma lusitanicum. The acaricidal effects of compound 24 were four times higher than that of germacrone ( 1 ). Compound 2 is an insect antifeedant a thousand times more potent than germacrone against Rhopalosiphum padi , which makes this substance a promising selective antifeedant against this cereal pest.

Germacrone Derivatives as new Insecticidal and Acaricidal Compounds: A Structure-Activity Relationship