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Four new triterpenoids, 3β,12β,16β,21β,22-pentahydroxyhopane ( 1 ), 12β,16β,21β,22-tetrahydroxyhopan-3-one ( 2 ), 3-oxo-olean-12-ene-28,30-dioic acid ( 3 ), and 3β-hydroxyoleana-11,13(18)-diene-28,30-dioic acid 30-methyl ester ( 4 ); 21 new triterpenoid saponins, glinusopposides A-U ( 5 - 25 ); and 12 known compounds ( 26 - 37 ) were isolated from the whole plants of Glinus oppositifolius . The structures of the new compounds were elucidated based on the analysis of one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) and mass spectrometry (MS) data. All compounds from the plants were measured for antifungal activities against Microsporum gypseum and Trichophyton rubrum . Glinusopposide B ( 6 ), glinusopposide Q ( 21 ), glinusopposide T ( 24 ), and glinusopposide U ( 25 ) showed strong inhibitory activities against M. gypseum (MIC 50 7.1, 6.7, 6.8, and 11.1 μM, respectively) and T. rubrum (MIC 50 14.3, 13.4, 11.9, and 13.0 μM, respectively). For those active compounds with an oleanane skeleton, glycosylation ( 21 - 26 ) or oxidation ( 3 ) of 3-OH was helpful in increasing the activity; replacement of the 30-methyl group ( 29 ) by a carboxymethyl group ( 26 ) enhanced the activity; the presence of 11,13(18) double bonds ( 20 ) decreased the activity.

Triterpenoids and Their Glycosides from Glinus Oppositifolius with Antifungal Activities against Microsporum Gypseum and Trichophyton Rubrum