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Three new dimeric abietane-type diterpenoids, abieta-6,8,11,13-tetraen-12-yl 12-hydroxyabieta-8,11,13-trien-7α-yl peroxide ( 1 ), abieta-6,8,11,13-tetraen-12-yl 12-hydroxyabieta-8,11,13-trien-7β-yl peroxide ( 2 ), and 12-hydroxyabieta-8,11,13-trien-7β-yl 7-oxoabieta-5,8,11,13-tetraen-12-yl peroxide ( 3 ), together with four known abietane-type diterpenoids ( 4 – 7 ) were isolated from the methanol extract of the bark of  Cryptomeria japonica . Their structures were elucidated on the basis of spectroscopic analysis and comparison of NMR data with those of known analogues. At a concentration of 50 μM, compounds  1 ,  2 , and  3  showed 26.2%, 23.6%, and 35.7% inhibition towards xanthine oxidase enzyme, respectively. In addition, compound  3  also showed 24.9% inhibition toward angiotensin-converting enzyme (ACE).

Bioactive Dimeric Abietanoid Peroxides from the Bark of Cryptomeria japonica