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Synthesis of 1,2,3-triazole-substituted coumarins and also 1,2,3-triazolyl or 1,2,3-triazolylalk-1-inyl-linked coumarin-2,3-furocoumarin hybrids was performed by employing the cross-coupling and copper catalyzed azide-alkyne cycloaddition reaction approaches. The synthesized compounds were evaluated for their in vitro antibacterial activity against  Staphylococcus   aureus ,  Bacillius   subtilis ,  Actinomyces   viscosus  and  Escherichia   coli  bacterial strains. Coumarin-benzoic acid hybrids  4с ,  42с  and 3-((4-acetylamino-3-(methoxycarbonyl)phenyl)ethynyl)coumarin ( 29 ) showed promising activity against  S .  aureus  strains, and the 1,2,3-triazolyloct-1-inyl linked coumarin-2,3-furocoumarin hybrid  37c  was endowed with high selectivity against  B. subtilis  and  E. coli  species. The in vitro antibacterial activity of  4с ,  29 ,  37c  and  42с  can potentially be compared with that of a number of modern antibiotic drugs used in the clinic, suggesting promising prospects for further research. A detailed study of the molecular interactions with the targeted protein MurB was performed using docking simulations and the obtained results are quite promising.

Design, Synthesis and Antibacterial Activity of Coumarin-1,2,3-triazole Hybrids Obtained from Natural Furocoumarin Peucedanin