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Three furan-containing scalarane sesterterpenoids ( 1 ⁻ 3 ) and a novel pyrrole-containing analog ( 4 ) were isolated from the sponge Scalarispongia species. Compound 3 , reported in the literature as a synthetic derivative of furoscalarol 2 , was for the first time isolated from a natural source. During the separation performed using a silica column in the presence of methanol, 16-methoxy derivatives ( 5 , 6 ) were obtained from the unintended reaction of 2 . The isolated natural products 3 and 4 and the artifact 5 showed moderate to high cytotoxicity against six human cancer cell lines, whereas compound 6 , the C-16 epimer of 5 , showed no cytotoxicity at a concentration of 60 μΜ.

Cytotoxic Furan- and Pyrrole-Containing Scalarane Sesterterpenoids Isolated from the Sponge Scalarispongia sp.