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The synthesis of a new CF₃-containing stereogenic atropisomeric pair of ortho-disubstituted biphenyl scaffold is presented. The atropisomers are surprisingly conformationally stable for isolation. X-ray structures show that their stability comes from an intramolecular hydrogen bond formation from their two hydroxyl groups and renders the spatial arrangement of their peripheral CF₃ and CH₃ groups very different. The synthesized stereogenic scaffold proved to be effective in catalyzing the asymmetric N -nitroso aldol reaction of enamine and nitrosobenzene. Compared to similar scaffolds without CF₃ groups, one of our atropisomer exhibits an increase in enantioselectivity in this reaction.

Synthesis of a Conformationally Stable Atropisomeric Pair of Biphenyl Scaffold Containing Additional Stereogenic Centers