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Bioassay directed isolation of secondary metabolites from the rhizomes of Zingiber montanum (Fam. ‎Zingiberaceae) led to the isolation of mono-, sesqui-, and di-terpenes. The compounds were characterized as ( E )-8(17),12-labdadiene-15,16-dial ( 1 ), zerumbol ( 2 ), zerumbone ( 3 ), buddledone A ( 4 ), furanodienone ( 5 ), germacrone ( 6 ), borneol ( 7 ), and camphor ( 8 ) by analysing one-dimensional (1D) (¹H and 13 C) and two-dimensional (2D) (COSY, HSQC, HMBC, and NOESY) NMR data and mass spectra. Among these terpenes, compounds 1 and 2 revealed potential antibacterial activity (minimum inhibitory concentrations (MIC) values 32⁻128 µg/mL; 0.145⁻0.291 mM)) against a series of clinical isolates of multi-drug resistant (MDR) and Methicillin resistant Staphylococcus aureus (MRSA).

Terpenes from Zingiber montanum and Their Screening against Multi-Drug Resistant and Methicillin Resistant Staphylococcus aureus