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Intensive study on the chemical components of a Korean marine sponge, Spongia sp., has led to the isolation of four new scalarane sesterterpenes, scalalactams A⁻D ( 1 ⁻ 4 ). Their chemical structures were elucidated from the analysis of spectroscopic data including 1D-and 2D-NMR as well as MS data. Scalalactams A⁻D ( 1 ⁻ 4 ) possess a scalarane carbon skeleton with a rare structural feature of a γ-lactam moiety within the molecules. Scalalactams A and B ( 1 and 2 ) have an extended isopropanyl chain at the lactam ring, and scalalactams C and D ( 3 and 4 ) possess a phenethyl group at the lactam ring moiety. Scalalactams A⁻D ( 1 ⁻ 4 ) did not show FXR antagonistic activity nor cytotoxicity up to 100 μM.

Scalalactams A–D, Scalarane Sesterterpenes with a γ-Lactam Moiety from a Korean Spongia Sp. Marine Sponge