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A series of novel spirooxindole- O -naphthoquinone-tetrazolo[1,5- a ]pyrimidine hybrids were designed, synthesized and evaluated as potent antitumor agents. These hybrids exhibited relatively high cytotoxic activity against cancer cell line HepG2 (IC 50 = 2.86⁻36.34 μM), while normal cell line LO2 was less sensitive to these hybrids (IC 50 = 36.37⁻248.39 μM). On the whole, among all the compounds tested, compound 4e , with a mean IC 50 value of 2.86 μM, was the most active. The novel hybrids may find their pharmaceutical applications after further investigations.

Synthesis of Spirooxindole-O-Naphthoquinone-Tetrazolo[1,5-a]Pyrimidine Hybrids as Potential Anticancer Agents