English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

A novel fused system with three or four fused rings—pyridazino[3′,4′:5,6][1,2,4]triazino[4,3- b ][1,2,4,5]tetrazine and pyridazino[3′,4′:5,6][1,2,4]triazino[3,4- b ]pyrimido[4,5- e ][1,3,4]thiadiazine was obtained from the starting materials 4(6 H )-amino-3-hydrazino-7-(2-thienyl)pyridazino[3,4- e ][1,2,4]-triazine 2 and 9-amino-3-(2-thienyl)-2 H ,8 H -pyridazino[3′,4′:5,6][1,2,4]triazino[3,4- b ][1,3,4]thiadiazine-8-carbonitrile 12 . Each of the starting compounds was subjected to a number of cyclization reactions to obtain a series of new heterocyclic fused systems, 3 ⁻ 10 and 13 ⁻ 23 , via bifunctional reagents. Some of the synthesized compounds were screened against three cell lines including HepG2, HCT-116 and MCF-7 to discover their anticancer activity. The synthesized compounds were characterized depending on their elemental analyses and spectral data.

Synthesis and Pharmacological Studies of Unprecedented Fused Pyridazino[3′,4′:5,6][1,2,4]triazino[3,4-b][1,3,4]thiadiazine Derivatives