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New clerodane diterpenes, 12- epi -megalocarpodolide D ( 2 ) and an epimeric mixture of crotonolins A ( 3 ) and B ( 4 ), were isolated from the bark of Croton oligandrus following a bioassay-guided isolation protocol. Known compounds, megalocarpodolide D ( 1 ), 12- epi -crotocorylifuran ( 5 ), cluytyl-ferulate ( 6 ), hexacosanoyl- ferulate ( 7 ), vanillin ( 8 ), acetyl-aleuritolic acid ( 9 ) and lupeol ( 10 ), were also isolated. The structures of the isolated compounds ( 1 - 10 ) were elucidated by spectroscopic means. The cytotoxicity of compounds 1 - 10 was assessed against A549, MCF7, PC3 and PNT2 cell lines using the MTT assay. Compounds 1 and 2 showed moderate levels of activity against both A549 and MCF7 cells with 1 being the most active with IC 50 values of 63.8 ± 13.8 and 136.2 ± 22.7 µM against A549 and MCF7 cells, respectively. The epimeric mixture of 3 and 4 was moderately active against A549 and PC3 cells (IC 50 = 128.6 ± 31.0 and 111.2 ± 2.9 µM, respectively).

Ent-Clerodane Diterpenes from the Bark of Croton oligandrus Pierre ex Hutch. and Assessment of Their Cytotoxicity against Human Cancer Cell Lines