English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

In this study, a series of di- O -caffeoylquinic acids ( di-COQs ) were systematically investigated for their antioxidant and cytoprotective effects towards •OH-damaged bone marrow-derived mesenchymal stem cells (bmMSCs). Five di-COQs were measured using a set of antioxidant assays. The results show that adjacent 4,5-Di- O -caffeoylquinic acid ( 4 , 5-COQ ) and 3,4-di- O -caffeoylquinic acid ( 3 , 4-COQ ) always gave lower IC 50 values than did non-adjacent di-COQs . In the Fe 2+ -chelating assay, 4 , 5-COQ and 3 , 4-COQ presented greater UV-Vis spectra and darker colors than did non-adjacent di-COQs . In the UPLC-ESI-MS/MS analysis, no corresponding radical adduct formation (RAF) peak was found in the reaction products of di-COQs with PTIO•. In the MTT assay, all di-COQs (especially 1,5-COQ , 1,3-COQ , and 4 , 5-COQ ) dose-dependently increased the cellular viabilities of •OH-damaged bmMSCs. Based on this evidence, we conclude that the five antioxidant di-COQs can protect bmMSCs from •OH-induced damage. Their antioxidant mechanisms may include electron-transfer (ET), H⁺-transfer, and Fe 2+ -chelating, except for RAF. Two adjacent di-COQs ( 4 , 5-COQ and 3 , 4-COQ ) always possessed a higher antioxidant ability than the non-adjacent di-COQs ( 1 , 3-COQ , 1 , 5-COQ , and 3 , 5-COQ ) in chemical models. However, non-adjacent 1 , 3-COQ and 1 , 5-COQ exhibited a higher cytoprotective effect than did adjacent di-COQs. These differences can be attributed to the relative positions of two caffeoyl moieties and, ultimately, to the conformational effect from the cyclohexane skeleton.

molecules/molecules online/molecules annual

Antioxidant and Cytoprotective Effects of the Di-O-Caffeoylquinic Acid Family: The Mechanism, Structure–Activity Relationship, and Conformational Effect