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A series of novel oleanolic acid 3- O - β -d-glucuronopyranoside derivatives have been designed and synthesized. Biological evaluation has indicated that some of the synthesized compounds exhibit moderate to good activity against H₂O₂-induced injury in rat myocardial cells (H9c2). Particularly, derivative 28- N -isobutyl ursolic amide 3- O - β -d-galactopyranoside ( 8a ) exhibited a greater protective effect than the positive control oleanolic acid 3- O - β -d-glucuronopyranoside, indicating that it possesses a great potential for further development as a cardiovascular disease modulator by structural modification.

molecules/molecules online/molecules annual

Semisynthesis and Biological Evaluation of Oleanolic Acid 3-O-β-d-Glucuronopyranoside Derivatives for Protecting H9c2 Cardiomyoblasts against H2O2-Induced Injury