English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Efficient enzymatic resolutions are reported for the preparation of new eight-membered ring-fused enantiomeric β-amino acids [(1 R ,2 S )- 9 and (1 S ,2 R )- 9 ] and β-lactams [(1 S ,8 R )- 3 , (1 R ,8 S )- 3 (1 S ,8 R )- 4 and (1 R ,8 S )- 7 ], through asymmetric acylation of (±)- 4 ( E &gt; 100) or enantioselective hydrolysis ( E &gt; 200) of the corresponding inactivated (±)- 3 or activated (±)- 4 β-lactams, catalyzed by PSIM or CAL-B in an organic solvent. CAL-B-catalyzed ring cleavage of (±)- 6 ( E &gt; 200) resulted in the unreacted (1 S ,8 R )- 6 , potential intermediate for the synthesis of enantiomeric anatoxin- a . The best strategies, in view of E , reaction rate and product yields, which underline the importance of substrate engineering, are highlighted.

Efficient Enzymatic Routes for the Synthesis of New Eight-membered Cyclic β-Amino Acid and β-Lactam Enantiomers