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Tuberculosis is an infectious disease caused by Mycobacterium  tuberculosis , which triggers severe pulmonary diseases. Recently, multidrug/extensively drug-resistant tuberculosis strains have emerged and continue to threaten global health. Because of the development of drug-resistant tuberculosis, there is an urgent need for novel antibiotics to treat these drug-resistant bacteria. In light of the clinical importance of M . tuberculosis , 2067 structures of M . tuberculsosis proteins have been determined. Among them, 52 structures have been solved and studied using solution nuclear magnetic resonance (NMR). The functional details based on structural analysis of M . tuberculosis using NMR can provide essential biochemical data for the development of novel antibiotic drugs. In this review, we introduce diverse structural and biochemical studies on M . tuberculosis proteins determined using NMR spectroscopy.

Solution NMR Studies of Mycobacterium tuberculosis Proteins for Antibiotic Target Discovery