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Two new thymol derivatives, 7,9-diisobutyryloxy-8-ethoxythymol ( 1 ) and 7-acetoxy-8-methoxy-9-isobutyryloxythymol ( 2 ), were isolated from fresh roots of Ageratina adenophora , together with four known compounds, 7,9-di-isobutyryloxy-8-methoxythymol ( 3 ), 9-oxoageraphorone ( 4 ), (-)-isochaminic acid ( 5 ) and (1α,6α)-10-hydroxycar-3-ene-2-one ( 6 ). Their structures were established on the basis of detailed spectroscopic analysis, and they were all isolated from the roots of A. adenophora for the first time. All the compounds were tested for their in vitro antibacterial activity toward three Gram-positive and two Gram-negative bacterial strains. Thymol derivatives 1 - 3 only selectively showed slight in vitro bacteriostatic activity toward three Gram-positive bacteria. The two known carene-type monoterpenes 5 and 6 were found to show moderate in vitro antibacterial activity against all five tested bacterial strains, with MIC values from 15.6 to 62.5 μg/mL. In addition, compounds 5 and 6 were further revealed to show in vitro cytotoxicity against human tumor A549, HeLa and HepG2 cell lines, with IC 50 values ranging from 18.36 to 41.87 μM. However, their cytotoxic activities were inferior to those of reference compound adriamycin.

Two New Thymol Derivatives from the Roots of Ageratina adenophora