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A new phenylpropanoid glycoside ( 1 ), and two new coumarin glycosides ( 2 , 3 ), together with two known compounds ( 4 , 5 ), have been isolated from the stems of Hydrangea paniculata Sieb. Their structures have been determined by spectroscopic and chemical methods. Furthermore, compound 1 (50 μM) exhibited significant hepatoprotective activity against N -acetyl-p-aminophenol (APAP)-induced HepG2 cell damage in vitro assays.

New Phenylpropanoid and Coumarin Glycosides from the Stems of Hydrangea paniculata Sieb