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Some novel hydrazone derivatives 6a - o were synthesized from the key intermediate 4-Chloro- N -(2-hydrazinocarbonyl-phenyl)-benzamide 5 and characterized using IR, ¹H-NMR, 13 C-NMR, mass spectroscopy and elemental analysis. The inhibitory potential against two secretory phospholipase A₂ (sPLA₂), three protease enzymes and eleven bacterial strains were evaluated. The results revealed that all compounds showed preferential inhibition towards h GIIA isoform of sPLA₂ rather than DrG-IB with compounds 6l and 6e being the most active. The tested compounds exhibited excellent antiprotease activity against proteinase K and protease from Bacillus sp. with compound 6l being the most active against both enzymes. Furthermore, the maximum zones of inhibition against bacterial growth were exhibited by compounds; 6a , 6m , and 6o against P. aeruginosa ; 6a , 6b , 6d , 6f , 6l , 6m , 6n , and 6o against Serratia ; 6k against S. mutans ; and compounds 6a , 6d , 6e , 6m , and 6n against E. feacalis. The docking simulations of hydrazones 6a - o with GIIA sPLA₂, proteinase K and hydrazones 6a - e with glutamine-fructose-6-phosphate transaminase were performed to obtain information regarding the mechanism of action.

Synthesis, Antiphospholipase A2, Antiprotease, Antibacterial Evaluation and Molecular Docking Analysis of Certain Novel Hydrazones