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A novel series of bis (1,3,4-thiadiazole) derivatives were synthesized in one step methodology with good yields by condensation reaction between bis -hydrazonoyl chloride 1 and various reagents. The structures of the prepared compounds were confirmed by spectral data (IR, NMR, and MS), and elemental analysis. The anticancer activity against human breast carcinoma (MCF-7) cancer cell lines was evaluated in MTT assay. The results revealed that the bis -thiadiazole derivatives 5c , d , 7b , c and 9c had higher antitumor activity than the standard drug Imatinib.

One Pot Single Step Synthesis and Biological Evaluation of Some Novel Bis(1,3,4-thiadiazole) Derivatives as Potential Cytotoxic Agents