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Nine new pregnane alkaloids ( 1 - 9 ), together with eight known alkaloids ( 10 - 17 ), were isolated from the whole herb of Pachysandra terminalis . Their structures were elucidated on the basis of spectroscopic analyses. In addition, the isolates were examined for their ability to inhibit the migration of MDA-MB-231 cells induced by the chemokine epidermal growth factor (EGF). Alkaloids 1 , 5 , 7 , 9 , 12 , and 17 presented significant anti-metastasis activities compared with the positive reagent, LY294002.

Terminamines K–S, Antimetastatic Pregnane Alkaloids from the Whole Herb of Pachysandra terminalis