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Plasmodium falciparum  thioredoxin reductase ( Pf TrxR) has been identified as a potential drug target to combat growing antimalarial drug resistance. Medicines for Malaria Venture (MMV) has pre-screened and identified a set of 400 antimalarial compounds called the Malaria Box. From those, we have evaluated their mechanisms of action through inhibition of  Pf TrxR and found new active chemical scaffolds. Five compounds with significant  Pf TrxR inhibitory activity, with IC 50  values ranging from 0.9–7.5 µM against the target enzyme, were found out of the Malaria Box.

molecules/molecules online/molecules annual

Preliminary LC-MS Based Screening for Inhibitors of Plasmodium falciparum Thioredoxin Reductase (PfTrxR) among a Set of Antimalarials from the Malaria Box