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In the course of our ongoing efforts to identify marine-derived bioactive compounds, the marine cyanobacterium  Moorea producens  was investigated. The organic extract of the Red Sea cyanobacterium afforded one new cerebroside, mooreaside A ( 1 ), two new nucleoside derivatives, 3-acetyl-2′-deoxyuridine ( 2 ) and 3-phenylethyl-2′-deoxyuridine ( 3 ), along with the previously reported compounds thymidine ( 4 ) and 2,3-dihydroxypropyl heptacosanoate ( 5 ). The structures of the compounds were determined by different spectroscopic studies (UV, IR, 1D, 2D NMR, and HRESIMS), as well as comparison with the literature data. Compounds  1 – 5  showed variable cytotoxic activity against three cancer cell lines.

New Cerebroside and Nucleoside Derivatives from a Red Sea Strain of the Marine Cyanobacterium Moorea producens