English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The severity of infections caused by  Candida albicans , the most common opportunistic human fungal pathogen, needs rapid and effective antifungal treatments. One of the effective ways is to control the virulence factors of the pathogen. Therefore, the current study examined the effects of genistein, a natural isoflavone present in soybeans, on  C. albicans . The genistein-treated  C. albicans  cells were then exposed to macrophages. Although no inhibition effect on the growth rates of  C. albicans  was noted an enhancement of the immune response to macrophages has been observed, indicated by phagocytosis and release of cytokines TNF-α and IL-10. The effect of genistein on the enhanced phagocytosis can be mimicked by the fungicides fludioxonil or iprodione, which inhibit the histidine kinase Cos1p and lead to activation of HOG pathway. The western blot results showed a clear phosphorylation of Hog1p in the wild type strain of  C. albicans  after incubation with genistein. In addition, effects of genistein on the phosphorylation of Hog1p in the histidine kinase mutants  Δcos1  and  Δsln1  were also observed. Our results thus indicate a new bio-activity of genistein on  C. albicans  by activation of the HOG pathway of the human pathogen  C. albicans .

Regulation of Candida albicans Interaction with Macrophages through the Activation of HOG Pathway by Genistein