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Suzuki-Miyaura cross-coupling of 6-bromo-2-styrylquinazolin-4(3 H )-ones with arylboronic acids afforded a series of novel 6-aryl-2-styrylquinazolin-4(3 H )-ones. These compounds were evaluated for potential anticancer properties against the human renal (TK-10), melanoma (UACC-62) and breast cancer (MCF-7) cell lines. Their antimicrobial properties were also evaluated against six Gram-positive and four Gram-negative bacteria, as well as two strains of fungi. Molecular docking studies ( in silico ) were conducted on compounds  5a ,  b ,  d  and  6a ,  b ,  d – f  to recognize the hypothetical binding motif of the title compounds within the active site of the dihydrofolate reductase and thymidylate synthase enzymes.

Synthesis, Biological Evaluation and Molecular Docking Studies of 6-Aryl-2-Styrylquinazolin-4(3H)-Ones