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The interest of coumarins as antioxidant agents has attracted much attention in recent years. A quantitative structure-activity relationship (QSAR) study of the DPPH• (2,2-diphenyl-l- picrylhydrazyl) radical scavenging ability of chemical compounds, based on the 0-3D DRAGON molecular descriptors and an artificial neural networks (ANN) technique was developed. The built mathematical model showed a correlation coefficient for the training set (R 2 ) = 0.71, an external correlation coefficient (  2 ) = 0.65 and it was used to predict the antioxidant activity of 4-hydroxycoumarin derivatives. Besides, an experimental in vitro assay was developed for the reference compound of this group (4-hydroxycoumarin) and the results obtained confirmed the predictions made by the ANN.

&lt;strong&gt;DPPH&amp;bull; Free Radical Scavenging Activity of Coumarin Derivatives.&lt;em&gt; In Silico &lt;/em&gt;and&lt;em&gt; in Vitro &lt;/em&gt;Approach&lt;/strong&gt;