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This paper reviews data from numerous publications focused on the physicochemical parameters and chemical composition of ore-forming fluids from orogenic gold deposits formed during various geological epochs. The paper presents analysis of the distribution of the principal parameters of mineralizing fluids depending on the age of the mineralization. Some parameters of the fluids (their salinity and pressure) at orogenic gold deposits are demonstrated to systematically vary from older (median salinity 6.1 wt.%, median pressure 1680 bar) to younger (median salinity 3.6 wt.%, median pressure 1305 bar) deposits. The detected statistically significant differences between some parameters of mineralizing fluids at orogenic gold deposits are principally new information. The parameters at which mineralization of various age was formed are demonstrated to pertain to different depth levels of similar mineralization-forming systems. The fluid parameters of the most ancient deposits (which are mostly deeply eroded) correspond to the deepest levels of orogenic fluid systems. Hence, the detected differences in the salinity and pressure of the mineralizing fluids at orogenic deposits of different age reflect the vertical zoning of the mineralizing fluid systems.