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The present work aimed at assessing the pharmaceutical tableting properties of some Egyptian kaolin samples belong to the Abu Zenima kaolin deposits (estimated at 120 million tons). Four representative samples were selected based on kaolinite richness and their structural order-disorder degree, and after purification, they were dried at 70 °C and heated from room temperature up to 400 °C (10 °C/min). Mineralogy, micromorphology, microtexture, granulometry, porosimetry, moisture content, bulk and tapped density, direct and indirect flowability, and tableting characteristics are studied. Results indicated that purified kaolin samples were made up of 95–99% kaolinite,   0.7, crystallite size D001 u003e 30 nm) and disordered (HI u003c 0.7, D001 u003c 30 nm) kaolinite-rich samples have been improved (Hausner ratio between 1.24 and 1.09) as their densities were influenced by thermal treatment (with some observed changes in the kaolinite XRD reflection profiles) and by moisture content (variable between 2.98% and 5.82%). The obtained tablets exhibited hardness between 33 and 44 N only from the dehydrated powders at 400 °C, with elastic recovery (ER) between 21.74% and 25.61%, ejection stress (ES) between 7.85 and 11.45 MPa and tensile fracture stress (TFS) between 1.85 and 2.32 MPa, which are strongly correlated with crystallinity (HI) and flowability (HR) parameters. These findings on quality indicators showed the promising pharmaceutical tabletability of the studied Egyptian kaolin powders and the optimization factors for their manufacturability and compactability.

Flow and Tableting Behaviors of Some Egyptian Kaolin Powders as Potential Pharmaceutical Excipients