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Transposons of the Pseudomonas  aeruginosa accessory gene pool contribute to phenotype and to genome plasticity. We studied local P. aeruginosa strains to ascertain the encroachment of mer -type res site hunter transposons into clinical settings and their associations with other functional modules. Five different Tn 5053 family transposons were detected, all chromosomal. Some were solitary elements; one was in res of Tn 1013 #  , a relative of a reported carrier of int -type res site hunters (class 1 integrons), but most were in res of Tn 6603 , a new Tn 501 -related transposon of unknown phenotype. Most of the Tn 6603 ::Tn elements, and some Tn 6603 and Tn 6603 ::Tn elements found in GenBank sequences, were at identical sites in an hypothetical gene of P. aeruginosa genomic island PAGI-5v. The island in clonally differing strains was at either of two tRNA Lys loci, suggesting lateral transfer to these sites. This observation is consistent with the membership of the prototype PAGI-5 island to the ICE family of mobile genetic elements. Additionally, the res site hunters in the nested transposons occupied different positions in the Tn 6603 carrier. This suggested independent insertion events on five occasions at least. Tn 5053 family members that were mer -/ tni -defective were found in Tn 6603 - and Tn 501 -like carriers in GenBank sequences of non-clinical Pseudomonas spp. The transposition events in these cases presumably utilized tni functions in trans, as can occur with class 1 integrons. We suggest that in the clinical context, P. aeruginosa strains that carry Tn 6603 alone or in PAGI-5v can serve to disseminate functional res site hunters; these in turn can provide the requisite trans -acting tni functions to assist in the dissemination of class 1 integrons, and hence of their associated antibiotic resistance determinants.

Tn6603, a Carrier of Tn5053 Family Transposons, Occurs in the Chromosome and in a Genomic Island of Pseudomonas aeruginosa Clinical Strains