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We lack reliable methods to continuously assess localized, resting-state muscle activity that are comparable across individuals. Near-infrared spectroscopy (NIRS) provides a low-cost, non-invasive means to assess localized, resting-state muscle oxygen metabolism during venous or arterial occlusions (VO 2VO and VO 2AO , respectively). However, this technique is not suitable for continuous monitoring, and its utility is limited to those who can tolerate occlusions. Combining NIRS with diffuse correlated spectroscopy (DCS) enables continuous measurement of an index of muscle oxygen metabolism (VO 2i ). Despite the lack of previous validation, VO 2i is employed as a measure of oxygen metabolism in the muscle. Here we characterized measurement repeatability and compared VO 2i with VO 2VO and VO 2AO in the medial gastrocnemius (MG) in 9 healthy adults. Intra-participant repeatability of VO 2i , VO 2VO , and VO 2AO were excellent. VO 2i was not significantly correlated with VO 2AO ( p = 0.15) nor VO 2VO ( p = 0.55). This lack of correlation suggests that the variability in the calibration coefficient between VO 2i and VO 2AO /VO 2VO in the MG is substantial across participants. Thus, it is preferable to calibrate VO 2i prior to every monitoring session. Important future work is needed to compare VO 2i against gold standard modalities such as positron emission tomography or magnetic resonance imaging.

Diffuse Optical Spectroscopy Assessment of Resting Oxygen Metabolism in the Leg Musculature