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Sponge-derived fungi have recently attracted attention as an important source of interesting bioactive compounds. Aspergillus nomius NC06 was isolated from the marine sponge Neopetrosia chaliniformis . This fungus was cultured on rice medium and yielded four compounds including three new oxisterigmatocystins, namely, J, K, and L ( 1 , 2 , and 3 ), and one known compound, aspergillicin A ( 4 ). Structures of the compounds were elucidated by 1D and 2D NMR spectroscopy and by high-resolution mass spectrometry. The isolated compounds were tested for cytotoxic activity against HT 29 colon cancer cells, where compounds 1 , 2 , and 4 exhibited IC 50 values of 6.28, 15.14, and 1.63 µM, respectively. Under the fluorescence microscope by using a double staining method, HT 29 cells were observed to be viable, apoptotic, and necrotic after treatment with the cytotoxic compounds 1 , 2 , and 4 . The result shows that compounds 1 and 2 were able to induce apoptosis and cell death in HT 29 cells.

Apoptotic Activity of New Oxisterigmatocystin Derivatives from the Marine-Derived Fungus Aspergillus nomius NC06