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One new diterpenoid, diaporpenoid A ( 1 ), two new sesquiterpenoids, diaporpenoids B–C ( 2 , 3 ) and three new  α -pyrone derivatives, diaporpyrones A–C ( 4 – 6 ) were isolated from an MeOH extract obtained from cultures of the mangrove endophytic fungus  Diaporthe  sp. QYM12. Their structures were elucidated by extensive analysis of spectroscopic data. The absolute configurations were determined by electronic circular dichroism (ECD) calculations and a comparison of the specific rotation. Compound  1  had an unusual 5/10/5-fused tricyclic ring system. Compounds  1  and  4  showed potent anti-inflammatory activities by inhibiting the production of nitric oxide (NO) in lipopolysaccharide (LPS)-induced RAW264.7 cells with IC 50  values of 21.5 and 12.5 μM, respectively.

Metabolites with Anti-Inflammatory Activity from the Mangrove Endophytic Fungus Diaporthe sp. QYM12