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Chemical examination from the cultured soft coral Sarcophyton digitatum resulted in the isolation and structural identification of four new biscembranoidal metabolites, sardigitolides A-D ( 1 - 4 ), along with three previously isolated biscembranoids, sarcophytolide L ( 5 ), glaucumolide A ( 6 ), glaucumolide B ( 7 ), and two known cembranoids ( 8 and 9 ). The chemical structures of all isolates were elucidated on the basis of 1D and 2D NMR spectroscopic analyses. Additionally, in order to discover bioactivity of marine natural products, 1 - 8 were examined in terms of their inhibitory potential against the upregulation of inflammatory factor production in lipopolysaccharide (LPS)-stimulated murine macrophage J774A.1 cells and their cytotoxicities against a limited panel of cancer cells. The anti-inflammatory results showed that at a concentration of 10 µg/mL, 6 and 8 inhibited the production of IL-1 β to 68 ± 1 and 56 ± 1%, respectively, in LPS-stimulated murine macrophages J774A.1. Furthermore, sardigitolide B ( 2 ) displayed cytotoxicities toward MCF-7 and MDA-MB-231 cancer cell lines with the IC 50 values of 9.6 ± 3.0 and 14.8 ± 4.0 µg/mL, respectively.

marine drugs

New Biscembranoids Sardigitolides A–D and Known Cembranoid-Related Compounds from Sarcophyton digitatum: Isolation, Structure Elucidation, and Bioactivities