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Chemical study of the CH2Cl2-MeOH (1:1) extract from the sponge Haliclona sp. collected in Mayotte highlighted three new long-chain highly oxygenated polyacetylenes, osirisynes G-I ( 1 - 3 ) together with the known osirisynes A ( 4 ), B ( 5 ), and E ( 6 ). Their structures were elucidated by 1D and 2D NMR spectra and HRESIMS and MS/MS data. All compounds were evaluated on catalase and sirtuin 1 activation and on CDK7, proteasome, Fyn kinase, tyrosinase, and elastase inhibition. Five compounds ( 1 ; 3 - 6 ) inhibited proteasome kinase and two compounds ( 5 - 6 ) inhibited CDK7 and Fyn kinase. Osirisyne B ( 5 ) was the most active compound with IC 50 on FYNB kinase, CDK7 kinase, and proteasome inhibition of 18.44 µM, 9.13 µM, and 0.26 µM, respectively.

Osirisynes G-I, New Long-Chain Highly Oxygenated Polyacetylenes from the Mayotte Marine Sponge Haliclona sp.