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Three new polyketides, ketidocillinones A-C ( 1 - 3 ), were discovered from the extract of an Antarctica sponge-derived fungus Penicillium sp. HDN151272. All the structures were deduced by spectroscopic data, including NMR and HRESIMS. The absolute configuration of compound 3 was established by using ECD calculation. Compounds 1 - 3 can be slowly oxidized to quinone form when exposed to air. Ketidocillinones B and C ( 2 and 3 ) exhibited potent antibacterial activity against Pseudomonas aeurigenosa , Mycobacterium phlei, and MRCNS (methicillin-resistant coagulase-negative staphylococci ) with MIC values ranging from 1.56 to 25.00 µg/mL.

Antibacterial Polyketides from Antarctica Sponge-Derived Fungus Penicillium sp. HDN151272