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Marine-derived fungi have been reported to have great potential to produce structurally unique metabolites. Our investigation on secondary metabolites from marine-derived fungi resulted in the isolation of seven new polyketides (phomopsiketones D-G ( 1 - 4 ) and letendronols A-C ( 5 - 7 )) as well as one known xylarinol ( 8 ) in the cultural broth of Letendraea sp. Their structures and absolute configurations were elucidated using a set of spectroscopic and chemical methods, including HRESIMS, NMR, single-crystal X-ray diffraction, ECD calculation, and a modified version of Mosher's method. Compound 2 showed weak inhibition against nitric oxide production in lipopolysaccaride-activated macrophages with an IC 50 value of 86 μM.

New Polyketides from the Marine-Derived Fungus Letendraea Sp. 5XNZ4-2