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A recent goal of synthetic biology has been to identify new chassis that provide benefits lacking in model organisms.  Vibrio natriegens  is a marine Gram-negative bacterium which is an emergent synthetic biology chassis with inherent benefits: An extremely fast growth rate, genetic tractability, and the ability to grow on a variety of carbon sources (“feedstock flexibility”). Given these inherent benefits, we sought to determine its potential to heterologously produce natural products, and chose beta-carotene and violacein as test cases. For beta-carotene production, we expressed the beta-carotene biosynthetic pathway from the sister marine bacterium  Vibrio campbellii , as well as the mevalonate biosynthetic pathway from the Gram-positive bacterium  Lactobacillus acidophilus  to improve precursor abundance. Violacein was produced by expressing a biosynthetic gene cluster derived from  Chromobacterium violaceum . Not only was  V. natriegens  able to heterologously produce these compounds in rich media, illustrating its promise as a new chassis for small molecule drug production, but it also did so in minimal media using a variety of feedstocks. The ability for  V. natriegens  to produce natural products with multiple industrially-relevant feedstocks argues for continued investigations into the production of more complex natural products in this chassis.

Exploiting the Feedstock Flexibility of the Emergent Synthetic Biology Chassis Vibrio natriegens for Engineered Natural Product Production