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Four new compounds were isolated from the Vietnamese marine sediment-derived fungus Aspergillus flocculosus , one aspyrone-related polyketide aspilactonol G ( 2 ), one meroterpenoid 12-epi-aspertetranone D ( 4 ), two drimane derivatives ( 7 , 9 ), together with five known metabolites ( 1 , 3 , 5 , 6 , 8 , 10 ). The structures of compounds 1 - 10 were established by NMR and MS techniques. The absolute stereoconfigurations of compounds 1 and 2 were determined by a modified Mosher's method. The absolute configurations of compounds 4 and 7 were established by a combination of analysis of ROESY data and coupling constants as well as biogenetic considerations. Compounds 7 and 8 exhibited cytotoxic activity toward human prostate cancer 22Rv1, human breast cancer MCF-7, and murine neuroblastoma Neuro-2a cells.

Biologically Active Metabolites from the Marine Sediment-Derived Fungus Aspergillus flocculosus