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Three new benzofuranoids, asperfuranoids A-C ( 1 - 3 ), two new phenylpropanoid derivatives ( 6 and 7 ), and nine known analogues ( 4 , 5 , and 8 - 14 ) were isolated from the liquid substrate fermentation cultures of the mangrove endopytic fungus Aspergillus sp. ZJ-68. The structures of the new compounds were determined by extensive spectroscopic data interpretation. The absolute configurations of 1 - 3 were assigned via the combination of Mosher's method, and experimental and calculated electronic circular dichroism (ECD) data. Compounds 4 and 5 were a pair of enantiomers and their absolute configurations were established for the first time on the basis of their ECD spectra aided with ECD calculations. All isolated compounds ( 1 - 14 ) were evaluated for their enzyme inhibitory activity against α -glucosidase and antibacterial activities against four pathogenic bacteria ( Staphylococcus aureus , Escherichia coli , Bacillus subtilis , and Pseudomonas aeruginosa ). Among them, compound 6 exhibited potent inhibitory activity against α -glucosidase in a standard in vitro assay, with an IC 50 value of 12.4 μM, while compounds 8 and 11 showed activities against S. aureus , E. coli , and B. subtilis , with MIC values in the range of 4.15 to 12.5 μg/mL.

New Benzofuranoids and Phenylpropanoids from the Mangrove Endophytic Fungus, Aspergillus sp. ZJ-68