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Overexpression of the global regulator LaeA in a marine-derived fungal strain of Penicillium dipodomyis YJ-11 induced obvious morphological changes and metabolic variations. Further chemical investigation of the mutant strain afforded a series of sorbicillinoids including two new ones named 10,11-dihydrobislongiquinolide ( 1 ) and 10,11,16,17-tetrahydrobislongiquinolide ( 2 ), as well as four known analogues, bislongiquinolide ( 3 ), 16,17-dihydrobislongiquinolide ( 4 ), sohirnone A ( 5 ), and 2',3'-dihydrosorbicillin ( 6 ). The results support that the global regulator LaeA is a useful tool in activating silent gene clusters in Penicillium strains to obtain previously undiscovered compounds.

Discovery of Two New Sorbicillinoids by Overexpression of the Global Regulator LaeA in a Marine-Derived Fungus Penicillium dipodomyis YJ-11