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Three new lactones penicilactones A-C ( 1 - 3 ) were obtained from the mangrove-derived fungus Penicillium sp. TGM112. Their structures and absolute configurations were determined by detailed NMR, MS spectroscopic data, Mo 2 (OAc) 4 -induced electronic circular dichroism (ECD), and circular dichroism (CD) spectroscopy. Compound 1 showed antibacterial activity against Staphylococcus aureus with an MIC value of 6.25 μg/mL. Compound 2 showed insecticidal activity against newly hatched larvae of Culex quinquefasciatus with the LC 50 value of 78.5 (±0.58) μg/mL.

Bioactive Lactones from the Mangrove-Derived Fungus Penicillium sp. TGM112