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Two new dimeric 1,4-benzoquinone derivatives, peniquinone A ( 1 ) and peniquinone B ( 2 ), a new dibenzofuran penizofuran A ( 3 ), and a new pyrazinoquinazoline derivative quinadoline D (4), together with 13 known compounds ( 5 - 17 ), were isolated from a marine-derived fungus Penicillium sp. L129. Their structures, including absolute configurations, were elucidated by extensive spectroscopic data and electronic circular dichroism calculations. Compound 1 exhibited cytotoxicity against the MCF-7, U87 and PC3 cell lines with IC 50 values of 12.39 µM, 9.01 µM and 14.59 µM, respectively, while compound 2 displayed relatively weak cytotoxicity activities against MCF-7, U87 and PC3 cell lines with IC 50 values of 25.32 µM, 13.45 µM and 19.93 µM, respectively. Furthermore, compound 2 showed weak quorum sensing inhibitory activity against Chromobacterium  violaceum CV026 with an MIC value of 20 μg/well.

Dimeric 1,4-benzoquinone Derivatives with Cytotoxic Activities from the Marine-Derived Fungus Penicillium sp. L129