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Four angucycline glycosides were previously characterized from marine-derived Streptomyces sp. OC1610.4. Further investigation of this strain cultured on different fermentation media from that used previously resulted in the isolation of two new angucycline glycosides, vineomycins E and F ( 1 - 2 ), and five known homologues, grincamycin L ( 3 ), vineomycinone B 2 ( 4 ), fridamycin D ( 5 ), moromycin B ( 7 ), and saquayamycin B 1 ( 8 ). Vineomycin F ( 2 ) contains an unusual ring-cleavage deoxy sugar. All the angucycline glycosides isolated from Streptomyces sp. OC1610.4 were evaluated for their cytotoxic activity against breast cancer cells MCF-7, MDA-MB-231, and BT-474. Moromycin B ( 7 ), saquayamycin B 1 ( 8 ), and saquayamycin B ( 9 ) displayed potent anti-proliferation against the tested cell lines, with IC 50 values ranging from 0.16 to 0.67 μM. Saquayamycin B ( 9 ) inhibited the migration and invasion of MDA-MB-231 cells in a dose-dependent manner, as detected by Transwell and wound-healing assays.

marine drugs

Cytotoxic, Anti-Migration, and Anti-Invasion Activities on Breast Cancer Cells of Angucycline Glycosides Isolated from a Marine-Derived Streptomyces sp.