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Two new chloro-furanocembranolides ( 1 , 2 ) and two new 1,4-diketo cembranolides ( 3 , 4 ) were isolated from the crude extract of Leptogorgia sp. together with a new seco -furanocembranolide ( 5 ) and the known Z -deoxypukalide ( 6 ), rubifolide ( 7 ), scabrolide D ( 8 ) and epoxylophodione ( 9 ). Their structures were determined based on spectroscopic evidence. Four compounds: 1 , 2 , 7 and 8 were found to activate the proliferation of pancreatic insulin-producing (beta) cells.

Chloro-Furanocembranolides from Leptogorgia sp. Improve Pancreatic Beta-Cell Proliferation