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Two new alkaloids, strepchazolins A ( 1 ) and B ( 2 ), together with a previously reported compound, streptazolin ( 3 ), were isolated from a marine actinomycete, Streptomyces chartreusis NA02069, collected in the Coast of Hainan Island, China. The structures of new compounds were determined by extensive NMR, mass spectroscopic and X-ray crystallographic analysis, as well as modified Mosher's method. Compound 1 showed weak anti- Bacillus subtilis activity with the MIC value of 64.0 μM, and weak inhibitory activity against acetylcholinesterase (AChE) in vitro with IC 50 value of 50.6 μM, while its diastereoisomer, Compound 2 , is almost inactive.

Strepchazolins A and B: Two New Alkaloids from a Marine Streptomyces chartreusis NA02069