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Seven new marine 11-acetoxy-9,11-secosterols, pinnisterols D-J ( 1 - 7 ), with a 1,4-quinone moiety, were discovered from the gorgonian coral Pinnigorgia sp. In this study, the structures of secosterols 1 - 7 were revealed by spectroscopic analysis. Bioactivity study showed that secosterol 1 treatment inhibited cell viability in a hepatic stellate cell line, HSC-T6, with an IC 50 value of 3.93 μM; and secosterols 2 , 5 , and 7 reduced elastase enzyme release, and 3 , 5 , and 7 decreased the production of superoxide anions from human neutrophils.

Pinnisterols D–J, New 11-Acetoxy-9,11-secosterols with a 1,4-Quinone Moiety from Formosan Gorgonian Coral Pinnigorgia sp. (Gorgoniidae)