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Chemical investigation of the cultures of marine  Streptomyces  sp. 182SMLY led to the discovery of two new polycyclic anthraquinones, which were elucidated as  N -acetyl- N -demethylmayamycin ( 1 ) and streptoanthraquinone A ( 2 ) based on the extensive spectroscopic analysis including 2D NMR, HRESIMS, and an electronic circular dichroism (ECD) calculation. Both anthraquinones remarkably suppressed the proliferation of four different glioma cell lines with IC 50  values in a range from 0.5 to 7.3 μM and induced apoptosis in the glioma cells. The ratios of IC 50  for normal human astrocytes to IC 50  for glioma cells were 6.4–53 for  1  and >14–31 for  2 .  N -acetyl- N -demethylmayamycin ( 1 ) also inhibited the growth of methicillin-resistant  Staphylococcus aureus  with MIC 20.0 μM.

Bioactive Polycyclic Quinones from Marine Streptomyces sp. 182SMLY